|
rs17655
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of lung
|
|
0.070 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Carcinoma of lung
|
|
0.070 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Primary malignant neoplasm of lung
|
|
0.070 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the colorectal cancer risk and the rs3212986(ERCC1) and rs17655(ERCC5) polymorphisms.
|
31568607 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of colon and/or rectum
|
|
0.060 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the colorectal cancer risk and the rs3212986(ERCC1) and rs17655(ERCC5) polymorphisms.
|
31568607 |
2019 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of stomach
|
|
0.060 |
GeneticVariation |
BEFREE |
The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, <i>P</i> = 0.037] were associated with the long-term survival of GC cases.
|
31558863 |
2019 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Stomach Carcinoma
|
|
0.060 |
GeneticVariation |
BEFREE |
The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, <i>P</i> = 0.037] were associated with the long-term survival of GC cases.
|
31558863 |
2019 |
|
rs2296147
|
ERCC5;BIVM-ERCC5
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation |
BEFREE |
None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (<i>P</i> = 0.050).
|
31558863 |
2019 |
|
rs2296147
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of stomach
|
|
0.030 |
GeneticVariation |
BEFREE |
None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (<i>P</i> = 0.050).
|
31558863 |
2019 |
|
rs751402
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs751402
|
ERCC5;BIVM-ERCC5
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of lung
|
|
0.070 |
GeneticVariation |
BEFREE |
XPC K939Q, XPA 5'UTR, XPG F670W and XPG D1104H had the best ability to predict lung cancer risk (CVC = 100, p < 0.0001).
|
31195348 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Primary malignant neoplasm of lung
|
|
0.070 |
GeneticVariation |
BEFREE |
XPC K939Q, XPA 5'UTR, XPG F670W and XPG D1104H had the best ability to predict lung cancer risk (CVC = 100, p < 0.0001).
|
31195348 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Carcinoma of lung
|
|
0.070 |
GeneticVariation |
BEFREE |
XPC K939Q, XPA 5'UTR, XPG F670W and XPG D1104H had the best ability to predict lung cancer risk (CVC = 100, p < 0.0001).
|
31195348 |
2019 |
|
rs1323697
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four independent SNPs associated with BC risk, BIVM-ERCC5 rs1323697_C (OR = 1.06, 95% CI = 1.03-1.10), GTF2H4 rs1264308_T (OR = 0.93, 95% CI = 0.89-0.97), COPS2 rs141308737_C deletion (OR = 1.06, 95% CI = 1.03-1.09) and ELL rs1469412_C (OR = 0.93, 95% CI = 0.90-0.96).
|
31026346 |
2019 |
|
rs1323697
|
ERCC5;BIVM-ERCC5
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified four independent SNPs associated with BC risk, BIVM-ERCC5 rs1323697_C (OR = 1.06, 95% CI = 1.03-1.10), GTF2H4 rs1264308_T (OR = 0.93, 95% CI = 0.89-0.97), COPS2 rs141308737_C deletion (OR = 1.06, 95% CI = 1.03-1.09) and ELL rs1469412_C (OR = 0.93, 95% CI = 0.90-0.96).
|
31026346 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
In subgroup analysis, the significant association between the rs1</span>7655 C allele and CRC risk was found in Asians and hospital-based subgroups.
|
30899401 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Malignant neoplasm of colon and/or rectum
|
|
0.060 |
GeneticVariation |
BEFREE |
<i>XPG</i> Asp1104His polymorphism increases colorectal cancer risk especially in Asians.
|
30899401 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
Taken together, our results suggested that the <i>XPG</i> rs17655 G > C polymorphism is a low-penetrance susceptibility locus for CRC.
|
30899401 |
2019 |
|
rs929424117
|
ERCC5;BIVM-ERCC5
|
Xeroderma Pigmentosum
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification of a ERCC5 c.2333T>C (L778P) Variant in Two Tunisian Siblings With Mild Xeroderma Pigmentosum Phenotype.
|
30838033 |
2019 |
|
rs929424117
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic investigation shows that both patients were carriers of an homozygous T to C transition at the nucleotide position c.2333, causing the leucine to proline amino acid change at the position 778 (p.Leu778Pro) of the <i>ERCC5</i> gene, and resulting in an XP-G phenotype.
|
30838033 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation |
BEFREE |
Our investigations demonstrate that genotypes for the ERCC5 rs17655 polymorphism may be not associated with overall cancer risk.
|
30539843 |
2018 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation |
BEFREE |
Our investigations demonstrate that genotypes for the ERCC5 rs17655 polymorphism may be not associated with overall cancer risk.
|
30539843 |
2018 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In a subgroup meta-analysis, the results suggest that the ERCC5 rs17655 polymorphism is probably associated with HNC risk in European, but the results should be interpreted with caution for the low number of studies.
|
30539843 |
2018 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation |
BEFREE |
In a subgroup meta-analysis, the results suggest that the ERCC5 rs17655 polymorphism is probably associated with HNC risk in European, but the results should be interpreted with caution for the low number of studies.
|
30539843 |
2018 |